Abstract
Polymers are the most multifaceted class of biomaterials that are routinely being used for biomedical applications ranging from surgical sutures to tissue engineering scaffolds, medical implants, and drug-eluting devices.
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References
Ramakrishna, S., et al. 2001. Biomedical applications of polymer-composite materials: a review. Composites Science and Technology 61(9): 1189–1224.
Nutton, V. 2012. Ancient medicine. Routledge.
Gomes, M.E., and R. Reis. 2004. Biodegradable polymers and composites in biomedical applications: from catgut to tissue engineering. Part 1 Available systems and their properties. International Materials Reviews 49(5): 261–273.
Nair, L.S., and C.T. Laurencin. 2007. Biodegradable polymers as biomaterials. Progress in Polymer Science 32(8): 762–798.
Ulery, B.D., L.S. Nair, and C.T. Laurencin. 2011. Biomedical applications of biodegradable polymers. Journal of Polymer Science Part B: Polymer Physics 49(12): 832–864.
Markets.com, M. Biomaterials Market [By Products (Polymers, Metals, Ceramics, Natural Biomaterials) & Applications (Cardiovascular, Orthopedic, Dental, Plastic Surgery, Wound Healing, Tissue Engineering, Ophthalmology, Neurology Disorders)]—Global Forecasts to 2017. 2013.
Ozdil, D., and H.M. Aydin. 2014. Polymers for medical and tissue engineering applications. Journal of Chemical Technology and Biotechnology 89(12): 1793–1810.
Li, S. 1999. Hydrolytic degradation characteristics of aliphatic polyesters derived from lactic and glycolic acids. Journal of Biomedical Materials Research 48(3): 342–353.
Damodaran, V.B., et al. 2012. S-Nitrosated biodegradable polymers for biomedical applications: synthesis, characterization and impact of thiol structure on the physicochemical properties. Journal of Materials Chemistry 22(13): 5990–6001.
Gunatillake, P., R. Mayadunne, and R. Adhikari. 2006. Recent developments in biodegradable synthetic polymers. Biotechnology Annual Review 12: 301–347.
Katz, A., and R. Turner. 1970. Evaluation of tensile and absorption properties of polyglycolic acid sutures. Surgery, gynecology & obstetrics 131(4): 701.
Pihlajamäki, H.K., et al. 2010. Tissue restoration after implantation of polyglycolide, polydioxanone, polylevolactide, and metallic pins in cortical bone: an experimental study in rabbits. Calcified Tissue International 87(1): 90–98.
Wang, L., et al. 2010. Osteogenic differentiation of human umbilical cord mesenchymal stromal cells in polyglycolic acid scaffolds. Tissue Engineering Part A 16(6): 1937–1948.
Dunkelman, N.S., et al. 1995. Cartilage production by rabbit articular chondrocytes on polyglycolic acid scaffolds in a closed bioreactor system. Biotechnology and Bioengineering 46(4): 299–305.
Moran, J.M., D. Pazzano, and L.J. Bonassar. 2003. Characterization of polylactic acid-polyglycolic acid composites for cartilage tissue engineering. Tissue Engineering 9(1): 63–70.
Ohara, T., et al. 2010. Evaluation of scaffold materials for tooth tissue engineering. Journal of Biomedical Materials Research, Part A 94(3): 800–805.
Xu, L., et al. 2010. In vivo engineering of a functional tendon sheath in a hen model. Biomaterials 31(14): 3894–3902.
Navissano, M., et al. 2005. Neurotube® for facial nerve repair. Microsurgery 25(4): 268–271.
Tian, L., M.P. Prabhakaran, and S. Ramakrishna. 2015. Strategies for regeneration of components of nervous system: scaffolds, cells and biomolecules. Regenerative Biomaterials rbu017.
Abbushi, A., et al. 2008. Regeneration of intervertebral disc tissue by resorbable cell-free polyglycolic acid-based implants in a rabbit model of disc degeneration. Spine 33(14): 1527–1532.
Middleton, J.C., and A.J. Tipton. 2000. Synthetic biodegradable polymers as orthopedic devices. Biomaterials 21(23): 2335–2346.
Maurus, P.B., and C.C. Kaeding. 2004. Bioabsorbable implant material review. Operative Techniques in Sports Medicine 12(3): 158–160.
Kirby, G.T., et al. 2011. PLGA-based microparticles for the sustained release of BMP-2. Polymers 3(1): 571–586.
Zheng, Z., et al. 2010. The use of BMP-2 coupled–Nanosilver-PLGA composite grafts to induce bone repair in grossly infected segmental defects. Biomaterials 31(35): 9293–9300.
Uematsu, K., et al. 2005. Cartilage regeneration using mesenchymal stem cells and a three-dimensional poly-lactic-glycolic acid (PLGA) scaffold. Biomaterials 26(20): 4273–4279.
Ouyang, H.W., et al. 2002. The efficacy of bone marrow stromal cell-seeded knitted PLGA fiber scaffold for achilles tendon repair. Annals of the New York Academy of Sciences 961(1): 126–129.
Lee, J.J., et al. 2007. Investigation on biodegradable PLGA scaffold with various pore size structure for skin tissue engineering. Current Applied Physics 7: e37–e40.
de Ruiter, G.C., et al. 2008. Accuracy of motor axon regeneration across autograft, single lumen, and multichannel poly (lactic-co-glycolic acid)(PLGA) nerve tubes. Neurosurgery 63(1): 144.
de Ruiter, G.C., et al. 2008. Methods for in vitro characterization of multichannel nerve tubes. Journal of Biomedical Materials Research, Part A 84(3): 643–651.
Nair, L.S. and C.T. Laurencin. 2006. Polymers as biomaterials for tissue engineering and controlled drug delivery. In Tissue engineering I, 47–90. New York: Springer.
Chiari, C., et al. 2006. A tissue engineering approach to meniscus regeneration in a sheep model. Osteoarthritis and cartilage 14(10): 1056–1065.
Williams, J.M., et al. 2005. Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sintering. Biomaterials 26(23): 4817–4827.
Hollister, S.J. 2005. Porous scaffold design for tissue engineering. Nature Materials 4(7): 518–524.
Oh, S.H., et al. 2007. In vitro and in vivo characteristics of PCL scaffolds with pore size gradient fabricated by a centrifugation method. Biomaterials 28(9): 1664–1671.
Wei, B., et al. 2015. Three-dimensional polycaprolactone–hydroxyapatite scaffolds combined with bone marrow cells for cartilage tissue engineering. Journal of Biomaterials Applications 30(2): 160–170.
Ouyang, H.W., et al. 2003. Knitted poly-lactide-co-glycolide scaffold loaded with bone marrow stromal cells in repair and regeneration of rabbit Achilles tendon. Tissue Engineering 9(3): 431–439.
Chong, E., et al. 2007. Evaluation of electrospun PCL/gelatin nanofibrous scaffold for wound healing and layered dermal reconstitution. Acta Biomaterialia 3(3): 321–330.
Ghasemi-Mobarakeh, L., et al. 2008. Electrospun poly (ɛ-caprolactone)/gelatin nanofibrous scaffolds for nerve tissue engineering. Biomaterials 29(34): 4532–4539.
Zhang, Z., et al. 2006. The in vivo and in vitro degradation behavior of poly (trimethylene carbonate). Biomaterials 27(9): 1741–1748.
Liao, H., et al. 2011. Injectable calcium phosphate cement with PLGA, gelatin and PTMC microspheres in a rabbit femoral defect. Acta Biomaterialia 7(4): 1752–1759.
Habraken, W.J., et al. 2008. Introduction of enzymatically degradable poly (trimethylene carbonate) microspheres into an injectable calcium phosphate cement. Biomaterials 29(16): 2464–2476.
Sharifi, S., et al. 2012. Biodegradable nanocomposite hydrogel structures with enhanced mechanical properties prepared by photo-crosslinking solutions of poly (trimethylene carbonate)–poly (ethylene glycol)–poly (trimethylene carbonate) macromonomers and nanoclay particles. Acta Biomaterialia 8(12): 4233–4243.
Kluin, O.S., et al. 2009. A surface-eroding antibiotic delivery system based on poly-(trimethylene carbonate). Biomaterials 30(27): 4738–4742.
Neut, D., et al. 2009. A biodegradable antibiotic delivery system based on poly-(trimethylene carbonate) for the treatment of osteomyelitis. Acta Orthopaedica 80(5): 514–519.
Ertel, S.I., and J. Kohn. 1994. Evaluation of a series of tyrosine-derived polycarbonates as degradable biomaterials. Journal of Biomedical Materials Research 28(8): 919–930.
Bourke, S.L., and J. Kohn. 2003. Polymers derived from the amino acid L-tyrosine: polycarbonates, polyarylates and copolymers with poly (ethylene glycol). Advanced Drug Delivery Reviews 55(4): 447–466.
Tangpasuthadol, V., et al. 2000. Hydrolytic degradation of tyrosine-derived polycarbonates, a class of new biomaterials. Part II: 3-yr study of polymeric devices. Biomaterials 21(23): 2379–2387.
Kohn, J., W.J. Welsh, and D. Knight. 2007. A new approach to the rationale discovery of polymeric biomaterials. Biomaterials 28(29): 4171–4177.
Guda, T., et al. 2014. Methods to analyze bone regenerative response to different rhBMP-2 doses in rabbit craniofacial defects. Tissue Engineering Part C: Methods 20(9): 749–760.
Kim, J., et al. 2012. Bone regeneration in a rabbit critical-sized calvarial model using tyrosine-derived polycarbonate scaffolds. Tissue Engineering Part A 18(11–12): 1132–1139.
Magno, M.H.R., et al. 2010. Synthesis, degradation and biocompatibility of tyrosine-derived polycarbonate scaffolds. Journal of Materials Chemistry 20(40): 8885–8893.
Bhatnagar, D., et al. 2015. Hydrogel implant coatings for peripheral nerve regeneration in society for biomaterials. Charolette, North Carolina.
Ezra, M., et al. 2013. Enhanced femoral nerve regeneration after tubulization with a tyrosine-derived polycarbonate terpolymer: effects of protein adsorption and independence of conduit porosity. Tissue Engineering Part A 20(3–4): 518–528.
Lo, M.-C., et al. 2015. Coating flexible probes with an ultra fast degrading polymer to aid in tissue insertion. Biomedical Microdevices 17(2): 1–11.
Johnson, P.A., et al. 2010. Interplay of anionic charge, poly (ethylene glycol), and iodinated tyrosine incorporation within tyrosine-derived polycarbonates: Effects on vascular smooth muscle cell adhesion, proliferation, and motility. Journal of Biomedical Materials Research, Part A 93(2): 505–514.
Kohn, J. and J. Zeltinger. 2005. Degradable, drug-eluting stents: a new frontier for the treatment of coronary artery disease. Expert Review of Medical Devices 2(6):667–671.
Macri, L.K., et al. 2012. Ultrafast and fast bioerodible electrospun fiber mats for topical delivery of a hydrophilic peptide. Journal of Controlled Release 161(3): 813–820.
Bonzani, I.C., et al. 2007. Synthesis of two-component injectable polyurethanes for bone tissue engineering. Biomaterials 28(3): 423–433.
Saad, B., et al. 1997. Development of degradable polyesterurethanes for medical applications: in vitro and in vivo evaluations. Journal of Biomedical Materials Research 36(1): 65–74.
Grenier, S., M. Sandig, and K. Mequanint. 2007. Polyurethane biomaterials for fabricating 3D porous scaffolds and supporting vascular cells. Journal of Biomedical Materials Research, Part A 82(4): 802–809.
Lloyd, L., et al. 1998. Carbohydrate polymers as wound management aids. Carbohydrate Polymers 37(3): 315–322.
Bhatnagar, D., et al. 2013. Rheological characterization of novel HA-Pluronic thermoreversible hydrogels. Journal of Chemical and Biological Interfaces 1(2): 93–99.
Bhatnagar, D., et al. 2014. Hyaluronic acid and gelatin clay composite hydrogels: substrates for cell adhesion and controlled drug delivery. Journal of Chemical and Biological Interfaces 2(1): 34–44.
Choi, K.Y., et al. 2010. Self-assembled hyaluronic acid nanoparticles for active tumor targeting. Biomaterials 31(1): 106–114.
Zavan, B., et al. 2009. Hyaluronan based porous nano-particles enriched with growth factors for the treatment of ulcers: a placebo-controlled study. Journal of Materials Science Materials in Medicine 20(1): 235–247.
Choi, K.Y., et al. 2009. Self-assembled hyaluronic acid nanoparticles as a potential drug carrier for cancer therapy: synthesis, characterization, and in vivo biodistribution. Journal of Materials Chemistry 19(24): 4102–4107.
Fernandez, M.J., M.F. Freire, and M.S. Rey. 2004. Hyaluronic acid nanoparticles, Google Patents.
Heijink, A., et al. 2006. Local antibiotic delivery with OsteoSet (R), DBX (R), and collagraft (R). Clinical Orthopaedics and Related Research 451: 29–33.
Hirakura, T., et al. 2010. Hybrid hyaluronan hydrogel encapsulating nanogel as a protein nanocarrier: new system for sustained delivery of protein with a chaperone-like function. Journal of Controlled Release 142(3): 483–489.
Lee, F., J.E. Chung, and M. Kurisawa. 2009. An injectable hyaluronic acid–tyramine hydrogel system for protein delivery. Journal of Controlled Release 134(3): 186–193.
Ren, D., et al. 2005. The enzymatic degradation and swelling properties of chitosan matrices with different degrees of N-acetylation. Carbohydrate Research 340(15): 2403–2410.
Xia, W., P. Liu, and J. Liu. 2008. Advance in chitosan hydrolysis by non-specific cellulases. Bioresource technology 99(15): 6751–6762.
Azhar, F.F., A. Olad, and R. Salehi. 2014. Fabrication and characterization of chitosan–gelatin/nanohydroxyapatite–polyaniline composite with potential application in tissue engineering scaffolds. Designed Monomers and Polymers 17(7):654–667.
Ribeiro, M.P., et al. 2009. Development of a new chitosan hydrogel for wound dressing. Wound repair and regeneration 17(6): 817–824.
Im, O., et al. 2012. Biomimetic three-dimensional nanocrystalline hydroxyapatite and magnetically synthesized single-walled carbon nanotube chitosan nanocomposite for bone regeneration. International Journal of Nanomedicine 7: 2087.
Kumbar, S., C. Laurencin, and M. Deng. 2014. Natural and Synthetic Biomedical Polymers. Newnes.
Klöck, G., et al. 1997. Biocompatibility of mannuronic acid-rich alginates. Biomaterials 18(10): 707–713.
Chan, A.W., R.A. Whitney, and R.J. Neufeld. 2009. Semisynthesis of a controlled stimuli-responsive alginate hydrogel. Biomacromolecules 10(3): 609–616.
Wang, Q., et al. 2011. PLGA-chitosan/PLGA-alginate nanoparticle blends as biodegradable colloidal gels for seeding human umbilical cord mesenchymal stem cells. Journal of Biomedical Materials Research, Part A 96(3): 520–527.
Ölmez, S., et al. 2007. Chitosan and alginate scaffolds for bone tissue regeneration. Die Pharmazie-An International Journal of Pharmaceutical Sciences 62(6): 423–431.
Qi, X., J. Ye, and Y. Wang. 2009. Alginate/poly (lactic-co-glycolic acid)/calcium phosphate cement scaffold with oriented pore structure for bone tissue engineering. Journal of Biomedical Materials Research, Part A 89(4): 980–987.
Wittmer, C.R., et al. 2008. Multilayer nanofilms as substrates for hepatocellular applications. Biomaterials 29(30): 4082–4090.
Ribeiro, C., C. Barrias, and M. Barbosa. 2004. Calcium phosphate-alginate microspheres as enzyme delivery matrices. Biomaterials 25(18): 4363–4373.
Chan, L., H. Lee, and P. Heng. 2002. Production of alginate microspheres by internal gelation using an emulsification method. International Journal of Pharmaceutics 242(1): 259–262.
Ribeiro, A.J., et al. 2005. Chitosan-reinforced alginate microspheres obtained through the emulsification/internal gelation technique. European Journal of Pharmaceutical Sciences 25(1): 31–40.
Jockenhoevel, S. and T.C. Flanagan. 2011. Cardiovascular tissue engineering based on fibrin-gel-scaffolds. INTECH Open Access Publisher.
Jackson, M.R. 2001. Fibrin sealants in surgical practice: an overview. The American journal of surgery 182(2): S1–S7.
Spotnitz, W.D. 2014. Fibrin sealant: the only approved hemostat, sealant, and adhesive—a laboratory and clinical perspective. ISRN surgery, 2014.
Osathanon, T., et al. 2008. Microporous nanofibrous fibrin-based scaffolds for bone tissue engineering. Biomaterials 29(30): 4091–4099.
Karp, J.M., et al. 2004. Fibrin-filled scaffolds for bone-tissue engineering: An in vivo study. Journal of Biomedical Materials Research, Part A 71(1): 162–171.
Currie, L.J., J.R. Sharpe, and R. Martin. 2001. The use of fibrin glue in skin grafts and tissue-engineered skin replacements. Plastic and Reconstructive Surgery 108: 1713–1726.
Ye, Q., et al. 2000. Fibrin gel as a three dimensional matrix in cardiovascular tissue engineering. European Journal of Cardio-Thoracic Surgery 17(5): 587–591.
Kalbermatten, D.F., et al. 2008. Fibrin matrix for suspension of regenerative cells in an artificial nerve conduit. Journal of Plastic, Reconstructive and Aesthetic Surgery 61(6): 669–675.
Spicer, P.P., and A.G. Mikos. 2010. Fibrin glue as a drug delivery system. Journal of Controlled Release 148(1): 49–55.
Yuan, Z., et al. 2011. Biomaterial selection for tooth regeneration. Tissue Engineering Part B: Reviews 17(5): 373–388.
Lee, C.H., A. Singla, and Y. Lee. 2001. Biomedical applications of collagen. International Journal of Pharmaceutics 221(1): 1–22.
Isobe, Y., et al. 2012. Oriented collagen scaffolds for tissue engineering. Materials 5(3): 501–511.
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Damodaran, V.B., Bhatnagar, D., Murthy, N.S. (2016). Biomedical Polymers: An Overview. In: Biomedical Polymers. SpringerBriefs in Applied Sciences and Technology. Springer, Cham. https://doi.org/10.1007/978-3-319-32053-3_1
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DOI: https://doi.org/10.1007/978-3-319-32053-3_1
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